CAC_MISC 5-1993 Glossary Of Terms And Definitions
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DA1AA372D8B042508D4F590EDC89AA72 |
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文件大小(MB)： |
0.02 |
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页数： |
4 |
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日期： |
2004-12-12 |
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文本摘录（文本识别可能有误，但文件阅览显示及打印正常，pdf文件可进行文字搜索定位）：
CAC/MISC 5 Page 1 of 4,GLOSSARY OF TERMS AND DEFINITIONS,(RESIDUES OF VETERINARY DRUGS IN FOODS),CAC/MISC 5-1993,FOREWORD,The Glossary of Terms and Definitions has been elaborated by the Codex Committee on Residues,of Veterinary Drugs in Foods (CCRVDF) with a view towards providing information and guidance to the,Committee, and is intended for internal Codex use only.,The Glossary is intended to be an open list which is subject to review by the CCRVDF in order to,update, modify or add to the list of terms. Relevant terms elaborated by other Codex Committees are,included. Attention is drawn to the Notes following.,1. Acceptable Daily Intake (ADI): An estimate by JECFA of the amount of a veterinary drug,expressed on a body weight basis, that can be ingested daily over a lifetime without appreciable,health risk (standard man = 60 kg) (See Note 3).,2. Bioavailable Residues: Those residues that can be shown, by means of an appropriate method,(e.g. Gallo-Torres method) to be absorbed into systemic circulation when fed to laboratory,animals (See Note 3).,3. Bound Residue: Residues derived from the covalent binding of the parent drug or a metabolite of,the drug and a cellular biological soluble or insoluble macromolecule. These residues are not,extractable from the macromolecule by exhaustive extraction, denaturation or solubilization,techniques. They do not result from the incorporation of metabolized, radiolabelled fragments of,the drug into endogenous compounds, or the same macromolecule by normal biosynthetic,pathways. Information concerning the calculation of bound residues may be found in Annex 3 of,the 34th Report of JECFA (pages 58-61, WHO TRS 788).,4. Egg: Egg (in shell) of domesticated chickens (hens).,5. Extractable Residue: Those residues extracted from tissues or biological fluids by means of,aqueous acidic or basic media, organic solvents and/or hydrolysis with enzymes (e.g. sulfatase or,glucuronidase) to hydrolyze conjugates. The extraction conditions must be such that the,compounds of interest are not destroyed (See Note 2).,6. Fish: Means any of the cold-blooded aquatic vertebrate animals commonly known as such. This,includes Pisces, Elasmobranchs and Cyclostomes. Aquatic mammals, invertebrate animals and,amphibians are not included. It should be noted, however, that this term may also apply to certain,invertebrates, particularly Cephalopods.,7. Good Practice in the Use of Veterinary Drugs (GPVD): Is the official recommended or,authorized usage including withdrawal periods, approved by national authorities, of veterinary,drugs under practical conditions (See Note 1).,CAC/MISC 5 Page 2 of 4,8. Marker Residue: A residue whose concentration decreases in a known relationship to the level of,total residues in tissues, eggs, milk or other animal tissues. A specific quantitative analytical,method for measuring the concentration of the residue with the required sensitivity must be,available (See Note 3).,9. Maximum Residue Limit for Veterinary Drugs (MRLVD): Is the maximum concentration of,residue resulting from the use of a veterinary drug (expressed in mg/kg or mg/kg on a fresh,weight basis) that is recommended by the Codex Alimentarius Commission to be legally permitted,or recognized as acceptable in or on a food (See Note 1).,It is based on the type and amount of residue considered to be without any toxicological hazard for,human health as expressed by the Acceptable Daily Intake (ADI), or on the basis of a temporary,ADI that utilizes an additional safety factor. It also takes into account other relevant public health,risks as well as food technological aspects.,When establishing an MRL, consideration is also given to residues that occur in food of plant,origin and/or the environment. Furthermore, the MRL may be reduced to be consistent with good,practices in the use of veterinary drugs and to the extent that practical analytical methods are,available.,10. Meat: The edible part of any mammal.,11. Milk: Exclusively the normal mammary secretion obtained from one or more milkings without,either addition thereto or extraction therefrom. The term may be used for milk treated without,altering its composition, or for milk the fat content of which has been standardized under domestic,legislation. The term may also be used in association with a word or words to designate the type,grade, origin and/or intended use of such milk or to describe the physical treatment or the,modification of composition to which it has been subjected, provided that the modification is,restricted to an addition and/or withdrawal of natural milk constituents. In international trade, the,origin of the m……
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